[HTML][HTML] The role of nitric oxide in cancer: master regulator or NOt?

FH Khan, E Dervan, DD Bhattacharyya… - International journal of …, 2020 - mdpi.com
Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

Nitric oxide in cancer metastasis

H Cheng, L Wang, M Mollica, AT Re, S Wu, L Zuo - Cancer letters, 2014 - Elsevier
Cancer metastasis is the spread and growth of tumor cells from the original neoplasm to
further organs. This review analyzes the role of nitric oxide (NO radical dot), a signaling …

Nitric oxide-driven nanotherapeutics for cancer treatment

Z Zhao, X Shan, H Zhang, X Shi, P Huang, J Sun… - Journal of Controlled …, 2023 - Elsevier
Nitric oxide (NO) is a gaseous molecule endowed with diverse biological functions, offering
vast potential in the realm of cancer treatment. Considerable efforts have been dedicated to …

NO news is not necessarily good news in cancer

S Ekmekcioglu, CH Tang… - Current cancer drug …, 2005 - ingentaconnect.com
The diatomic radical nitric oxide has been the focus of numerous studies involved with every
facet of cancer. It has been implicated in carcinogenesis, progression, invasion, metastasis …

Insights on the functional dualism of nitric oxide in the hallmarks of cancer

P Panneerselvan, K Vasanthakumar… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Nitric oxide (NO), a gaseous radical, governs a variety of physiological and pathological
processes, including cancer, pro-inflammatory signalling, and vasodilation. The family of …

Opportunities for nitric oxide in potentiating cancer immunotherapy

J Kim, SN Thomas - Pharmacological Reviews, 2022 - ASPET
Despite nearly 30 years of development and recent highlights of nitric oxide (NO) donors
and NO delivery systems in anticancer therapy, the limited understanding of exogenous …

Nitric oxide in tumour biology and cancer therapy. Part 2: therapeutic implications

GM Tozer, SA Everett - Clinical oncology, 1997 - Elsevier
In the first part of this review [1], the role of nitric oxide (NO) as a physiological messenger in
the microcirculation was described. It was concluded that NO contributes to the maintenance …

Tumors face NO problems?

JR Lancaster Jr, K Xie - Cancer Research, 2006 - AACR
The effect of nitric oxide (NO) synthase (NOS) II expression on cancer biology is unclear and
difficult to define, with multiple reports of pro-and anti-cancer actions. Here we address the …

Therapeutic potential of nitric oxide in cancer

B Bonavida, S Khineche, S Huerta-Yepez… - Drug resistance …, 2006 - Elsevier
In recent years, several novel approaches have been developed to overcome tumor cell
resistance to conventional therapeutics. Such approaches include genetic manipulations …

NOS2 as an emergent player in progression of cancer

DD Thomas, DA Wink - Antioxidants & redox signaling, 2017 - liebertpub.com
Although the inducible form of nitric oxide synthase (NOS2) was initially shown to be a major
player as an antitumor component of the immune response, more recent data have shown …