In recent years, an increasing number of studies have shown that there is an important
connection between nitric oxide (NO) and the pathology of malignant diseases, but we are …

Tumors are spatially heterogeneous, with regions of relative hypoxia and normoxia. The
tumor microenvironment is an important determinant of both tumor growth and response to a …

Among its many roles in cellular biology, nitric oxide (radical dot NO) has long been
associated with cancers both as a protumorigenic and as an antitumorigenic agent. The dual …

Nitric oxide (NO) is an important cell signaling molecule whose level is frequently elevated
in many tumors including that of lung. Cellular phenotypes and behaviors are influenced by …

Nitric oxide (NO) is a pleiotropic signalling molecule that subserves a wide variety of basic
cellular functions and also manifests itself pathophysiologically. As regards cancer and its …

Abnormal tumour vasculature has a significant impact on tumour progression and response
to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis …

The role of NO and cGMP signaling in tumor biology has been extensively studied during
the past three decades. However, whether the pathway is beneficial or detrimental in cancer …

Nitric oxide (NO) is a free radical that can target cellular biomolecules directly, or by means
of the activity of its metabolites (RNS) generated upon reaction with transition metals (eg …

Nitric oxide (NO) has been highlighted as an important agent in tumor processes. However,
a complete understanding of the mechanisms by which this simple diatomic molecule …