Hypoxia and blood flow heterogeneities are characteristics of solid tumours and are major
obstacles for therapy. Exploiting the biology of nitric oxide (NO), a small radical with multiple …

Nitric oxide (NO) is involved in various physiological functions and its role in tumorigenesis
has been well studied. A large majority of human and experimental tumors appear to …

Nitric oxide (NO) is a short-lived molecule required for many physiological functions,
produced from Larginine by NO synthases (NOS). It is a free radical, producing many …

The Nobel Price in Physiology and Medicine was awarded in 1998 to Drs. Furchgott,
Ignarro, and Murad for their discoveries concerning the Nitric oxide as a signaling …

Varied cellular expression and localisation of nitric oxide synthase (NOS) isoforms has been
shown in human cancers, including tumours of the breast, ovary, stomach, cervix and central …

Nitric oxide (NO) is an endogenous free radical that controls important physiological and
pathophysiological processes, including a role in cancer biology. NO can have a direct toxic …

The dual or biphasic responses of cancer to nitric oxide (NO) arise from its concentration
dependent ability to regulate tumor growth, migration, invasion, survival, angiogenesis, and …

Nitric oxide (NO) is known to have dichotomous effects on cancer biology, acting as a pro-or
antineoplastic agent. Low concentrations of NO are reported to promote tumor growth …

Melanoma patients experience inferior survival after biochemotherapy when their tumors
contain numerous cells expressing the inducible isoform of NO synthase (iNOS) and …

Nitric oxide (NO) holds promise as a cytotoxic agent against tumors, but its gaseous nature
and short half-life hinder direct administration to tumor tissues. Herein, we present novel 6, 9 …