Tumor cell-macrophage interactions change as the tumor progresses, and the generation of
nitric oxide (NO) by the inducible nitric oxide synthase (iNOS) plays a major role in this …

Significance: Nitric oxide (NO) is a physiopathological messenger generating different
reactive nitrogen species (RNS) according to hypoxic, acidic and redox conditions. Recent …

Nitric oxide (NO) has been invoked in nearly every normal and pathological condition
associated with human physiology. In tumor biology, nitrogen oxides have both positive and …

Significance: Breast cancer is the second leading cause of cancer-related deaths among
women in the United States. Development and progression of malignancy are associated …

The cancer tissue exists not as a single entity, but as a combination of different cellular
phenotypes which, taken together, dramatically contribute to the entirety of their ecosystem …

The role of nitric oxide (NO) in cancer progression has largely been studied in the context of
tumor NOS2 expression. However, pro-versus anti-tumor signaling is also affected by tumor …

Nitric oxide (NO) shows great role in tumor biology. Recent years, more and more
researches utilized NO donor in tumor targeting drug delivery and treatment. In this review …

There has been a significant clinical demand for lymph‐directed anti‐metastatic therapy as
tumor‐draining lymph nodes play pivotal roles in cancer metastasis which accounts for more …

It took nearly seven years to establish that'endothelium derived relaxing factor (EDRF)', an
elusive factor responsible for relaxation of vascular smooth muscle cells [1] was nothing …

The endogenous mediator of vasodilation, nitric oxide (NO), has been shown to be a potent
radiosensitizer. However, the underlying mode of action for its role as a radiosensitizer …