From pollutant gas to biological messenger: the diverse actions of nitric oxide in cancer.

PA Brennan, S Moncada - Annals of the Royal College of …, 2002 - ncbi.nlm.nih.gov
Nitric oxide (NO) has undergone an image change in recent years. Previously regarded as a
toxic pollutant gas, it has now become the subject of intense research in many fields of …

[HTML][HTML] Nitric oxide and cancer

J Muntané, M De la Mata - World journal of hepatology, 2010 - ncbi.nlm.nih.gov
Nitric oxide (NO) is a lipophilic, highly diffusible and short-lived physiological messenger
which regulates a variety of important physiological responses including vasodilation …

[HTML][HTML] S-Nitrosylation in TNF superfamily signaling pathway: Implication in cancer

S Plenchette, S Romagny, V Laurens, A Bettaieb - Redox Biology, 2015 - Elsevier
One of the key features of tumor cells is the acquisition of resistance to apoptosis. Thus,
novel therapeutic strategies that circumvent apoptotic resistance and result in tumor …

Role of nitric oxide in tumor angiogenesis

L Morbidelli, S Donnini, M Ziche - Angiogenesis in Brain Tumors, 2004 - Springer
Nitric oxide (NO) is an important signalling molecule that acts in many tissues to regulate
different physiological and pathological processes. We have contributed to demonstrate that …

Inducible nitric oxide synthase-time for reappraisal

P Lirk, G Hoffmann, J Rieder - Current Drug Targets …, 2002 - ingentaconnect.com
Inducible nitric oxide synthase (iNOS) is one of three key enzymes generating nitric oxide
(NO) from the amino acid L-arginine. iNOS-derived NO plays an important role in numerous …

The acidic tumor microenvironment promotes the reconversion of nitrite into nitric oxide: towards a new and safe radiosensitizing strategy

F Frérart, P Sonveaux, G Rath, A Smoos, A Meqor… - Clinical Cancer …, 2008 - AACR
Purpose: The biological status of nitrite recently evolved from an inactive end product of
nitric oxide catabolism to the largest intravascular and tissue storage of nitric oxide (NO) …

Nitric oxide in tumour biology and cancer therapy. Part 1: Physiological aspects

GM Tozer, SA Everett - Clinical Oncology, 1997 - Elsevier
In the early 1980s, the discovery that nitric oxide (NO) could be released from stimulated
endothelial cells, resulting in blood vessel dilation, represented the discovery of a …

Immunoregulatory and effector activities of nitric oxide and reactive nitrogen species in cancer

C Fionda, MP Abruzzese, A Santoni… - Current medicinal …, 2016 - ingentaconnect.com
Nitric Oxide (NO) is a signaling radical, highly diffusible pleiotropic regulator of a large set of
different molecular and biological pathways, including, neurotransmission, vasodilatation …

Controlled delivery of nitric oxide for cancer therapy

H Alimoradi, K Greish, AB Gamble… - Pharmaceutical …, 2019 - ingentaconnect.com
Nitric oxide (NO) is a short-lived, endogenously produced, signaling molecule which plays
multiple roles in mammalian physiology. Underproduction of NO is associated with several …

The role of nitric oxide in cancer

W Xu, LZ Liu, M Loizidou, M Ahmed, IG Charles - Cell research, 2002 - nature.com
Nitric oxide (NO) is a pleiotropic regulator, critical to numerous biological processes,
including vasodilatation, neurotransmission and macrophage-mediated immunity. The …