Papillomaviruses are small DNA viruses that are associated with benign and malignant
epithelial lesions, including> 95% of cervical cancers and≈ 20% of head and neck cancers …

Papillomaviruses (PVs) demonstrate both tissue and species tropisms. Because PVs
replicate only in terminally differentiating epithelium, the recent production of infectious PV …

Animal and human papillomaviruses (HPVs) replicate persistently in specific types of
stratified epithelia of their host. After the initial infection, the viral genome replicates at low …

Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes
as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is …

Although the papillomavirus structural proteins, L1 and L2, can spontaneously coassemble
to form virus-like particles, currently available methods for production of L1/L2 particles …

It has recently become possible to generate high-titer papillomavirus-based gene-transfer
vectors. The vectors, also known as papillomavirus pseudoviruses (PsV), have been useful …

Papillomaviruses have evolved a life cycle that is perfectly coordinated with the
differentiation process of the host epidermal tissue. The stratified epithelium of the …

Human and animal papillomaviruses have strict speн cies and tissue tropisms. The closed
circular genomic DNA is typically 7.6-7.9 kbp. It replicates in squamous epithelium of …

Papillomavirus life cycle is tightly coupled to epithelial cell differentiation, which has
hindered the investigation of many aspects of papillomavirus biology, including virion …

The organotypic raft culture system has allowed the study of the differentiation-dependent
aspects of the human papillomavirus (HPV) life cycle. However, genetic strategies to more …