Restricted germ cell loss through apoptosis is initiated in the fetal gonad around embryonic
day 13.5 (E13. 5) as part of normal germ cell development. The mechanism of this germ cell …

Apoptosis is the main cause of primordial germ cell and oocyte degeneration in the
developing fetal ovary. In this study we examined by immunohistochemistry and …

Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the
embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the …

Oocyte loss, either directly through attrition (germ cell death) or indirectly through follicular
atresia (somatic or granulosa cell death), is a fundamental event associated with defining …

Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice
that are mutant for Bclw display progressive and nearly complete testicular degeneration …

Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal
cells show a highly abnormal adult spermatogenesis accompanied by sterility. This appears …

Bax is a multidomain, proapoptotic member of the Bcl-2 family that is required for normal
spermatogenesis in mice. Despite its proapoptotic function, previous results found that Bax …

During normal spermatogenesis, more than half of the germ cells undergo apoptosis, but the
physiological significance and molecular mechanisms of this programmed cell death are …

Since the cloning of the bcl-2 gene in 1985, considerable progress has been made in
elucidating the function of Bcl-2 and related proteins in controlling apoptosis. Although much …

A large part of germ cells die apoptotically during testicular development in rodents. In the
present study, a wave of germ cell apoptosis was observed between days 10 and 30 of …