Stimulation of fibroblast growth factor receptor-1 (FGFR-1) is known to result in
phosphorylation of tyrosine 766 and the recruitment and subsequent activation of …

Stimulation of fibroblast growth factor receptor-1 (FGFR-1) expressed on endothelial cells
leads to cellular migration and proliferation. We have examined the role of the Src homology …

We have examined fibroblast growth factor (FGF) receptor-1 mediated signal transduction in
differentiation of endothelial cells (EC). The activated FGFR-1 couples to Ras through two …

Endothelial cells expressing fibroblast growth factor receptor-1 (FGFR-1) migrate and
proliferate in response to treatment with FGF. We analysed ligand-induced migration and …

The adaptor protein Shc (Src homology and collagen-containing protein) plays an important
role in the activation of signalling pathways downstream of RTKs (receptor tyrosine kinases) …

Despite much progress in recent years, the precise signalling events triggered by the
vascular-endothelial-growth-factor (VEGF) receptors, fms-like tyrosine kinase (Flt1) and …

Fibroblast growth factor receptor 3 (FGFR3) influences a diverse array of biological
processes, including cell growth, differentiation, and migration. Activating mutations in …

Using the cytoplasmic domain of fibroblast growth factor receptor 1 (FGFR1) as bait in a
yeast two-hybrid screen, Grb14 was identified as a FGFR1 binding partner. A kinase-inactive …

The molecular basis by which receptor tyrosine kinases (RTKs) recruit and phosphorylate
Src Homology 2 (SH2) domain-containing substrates has remained elusive. We used X-ray …

Fibroblast growth factor receptors (FGFRs) are a family of transmembrane tyrosine kinases
involved in signaling via interactions with the family of fibroblast growth factors. Alternative …