[HTML][HTML] B and T cells driving multiple sclerosis: identity, mechanisms and potential triggers
J Van Langelaar, L Rijvers, J Smolders… - Frontiers in …, 2020 - frontiersin.org
Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …
However, the effective use of anti-CD20 treatment now also reveals an important role for B …
B cells in multiple sclerosis: connecting the dots
Over the past two decades B cells have increasingly moved into the spotlight in multiple
sclerosis (MS) research. This interest was fuelled by growing understanding and acceptance …
sclerosis (MS) research. This interest was fuelled by growing understanding and acceptance …
[HTML][HTML] Cytokine-defined B cell responses as therapeutic targets in multiple sclerosis
Important antibody-independent pathogenic roles of B cells are emerging in autoimmune
diseases, including multiple sclerosis (MS). The contrasting results of different treatments …
diseases, including multiple sclerosis (MS). The contrasting results of different treatments …
The role of B cells in the immunopathogenesis of multiple sclerosis
T Gharibi, Z Babaloo, A Hosseini, F Marofi… - …, 2020 - Wiley Online Library
There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis
(MS). The success of B‐cell targeting therapies in MS highlighted the role of B cells …
(MS). The success of B‐cell targeting therapies in MS highlighted the role of B cells …
Reassessing B cell contributions in multiple sclerosis
There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …
well beyond their potential to become antibody-producing cells, including roles at the innate …
B cells in multiple sclerosis
H Wekerle - Autoimmunity, 2017 - Taylor & Francis
B lymphocytes have essential roles in the autoimmune pathogenesis of multiple sclerosis
(MS). They regulate the autoimmune response and participate in the development of the …
(MS). They regulate the autoimmune response and participate in the development of the …
B cells in multiple sclerosis—from targeted depletion to immune reconstitution therapies
MT Cencioni, M Mattoscio, R Magliozzi… - Nature Reviews …, 2021 - nature.com
Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …
Circulating immune cells in multiple sclerosis
AP Jones, AG Kermode, RM Lucas… - Clinical & …, 2017 - academic.oup.com
Circulating T and B lymphocytes contribute to the pathogenesis of the neuroinflammatory
autoimmune disease, multiple sclerosis (MS). Further progress in the development of MS …
autoimmune disease, multiple sclerosis (MS). Further progress in the development of MS …
[HTML][HTML] Involvement of CD8+ T Cells in Multiple Sclerosis
M Salou, B Nicol, A Garcia, DA Laplaud - Frontiers in immunology, 2015 - frontiersin.org
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …
characterized by focal demyelination patches associated with inflammatory infiltrates …
Update on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets
H von Büdingen, A Palanichamy… - European …, 2015 - karger.com
Background: Collectively, research on the role of B-cells in the pathogenesis of multiple
sclerosis (MS) illustrates how translational medicine has given rise to promising therapeutic …
sclerosis (MS) illustrates how translational medicine has given rise to promising therapeutic …