Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppressor and an
antagonist of the phosphoinositide-3 kinase (PI3K) pathway. We identified a 576–amino …

The PTEN (phosphatase and tensin homolog) phosphatase is unique in mammals in terms
of its tumor suppressor activity, exerted by dephosphorylation of the lipid second messenger …

GLUT1 is the facilitative transporter playing the major role in the internalization of glucose.
Basally, GLUT1 resides on vesicles located in a para-golgian area, and is translocated onto …

The tumor suppressor gene PTEN is a phosphoinositide phosphatase that is inactivated by
deletion and/or mutation in diverse human tumors. Wild-type PTEN is expressed both in the …

PTEN phosphatase is a potent tumor suppressor that regulates multiple cellular functions. In
the cytoplasm, PTEN dephosphorylates its primary lipid substrate, phosphatidylinositol 3, 4 …

Pten inactivation promotes cell survival in leukemia cells by activating glycolytic metabolism.
We found that targeting ribosomal protein S6 kinase 1 (S6K1) in Pten-deficient cells …

PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

The tumor suppressor gene PTEN encodes a 55-kDa enzyme that hydrolyzes both protein
phosphotyrosyl and 3-phosphorylated inositol phospholipids in vitro. We have found that the …

The tumour suppressor protein, PTEN (phosphatase and tensin homolog deleted on
chromosome 10), is a phosphatase that can dephosphorylate tyrosine-containing peptides …

PTEN, mutated in a variety of human cancers, is a dual specificity protein phosphatase and
also possesses D3-phosphoinositide phosphatase activity on phosphatidylinositol 3, 4, 5-tris …