cis-trans-cis-Ammine (cyclohexylamine) diacetatodichloroplatinum (IV) is an oral analog of
the platinum anti-cancer drug cisplatin that is currently in phase III clinical trials. Its active …

Structure-activity relationships that define the class of antitumor-active platinum compounds
were summarized in 1973.1 cis-Diamminedichloroplatinum (II)(cis-DDP) and related …

The structure–pharmacological activity relationships generally accepted for antitumor
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …

The research of new platinum drugs active towards cisplatin refractory/resistant tumors has
been mostly focussed on compounds with cis geometry because transplatin, the trans …

The limitations of cisplatin as an anticancer drug have stimulated the search for other
antitumor-active platinum complexes with improved pharmacological properties. The two …

A series of platinum compounds with an analogue structure to cisplatin have been
synthesized and their biological activity against HL-60 cancer cell line has been studied …

In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

Products from oxidative-addition reactions of H 2 O 2; with cis-diamineplatinum (II)
complexes have been studied by NMR and X-ray crystallography. Reaction of H 2 O 2 with …

Novel cis-and trans-configured bis (oxime) platinum (II) complexes have been synthesized
and characterized by elemental analyses, IR, electrospray ionization mass spectrometry …

Publisher Summary Cisplatin (cis-diamminedichloroplatinum II) is one of the group of
platinum coordination complexes, which possess antibiotic activity. Cisplatin causes the …