ORF9c and ORF10 as accessory proteins of SARS-CoV-2 in immune evasion

M Zandi - Nature Reviews Immunology, 2022 - nature.com
In a recent Perspective article in Nature Reviews Immunology (Wong, LY. R. & Perlman, S.
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related …

[HTML][HTML] Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response

Z Cao, H Xia, R Rajsbaum, X Xia, H Wang… - Cellular & molecular …, 2021 - nature.com
Understanding interactions between the host and SARS-CoV-2 is essential for developing
effective vaccines and therapeutics. Here, we report that SARS-CoV-2 usurps the host …

Immune evasion via SARS-CoV-2 ORF8 protein?

MD Park - Nature Reviews Immunology, 2020 - nature.com
In this preprint, Zhang et al. elucidate a potential immune evasion strategy involving the
SARS-CoV-2 ORF8 protein. They show that expression of ORF8, which directly binds to …

[HTML][HTML] SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy

X Li, P Hou, W Ma, X Wang, H Wang, Z Yu… - Cellular & molecular …, 2022 - nature.com
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and …

Atypical divergence of SARS-CoV-2 Orf8 from Orf7a within the coronavirus lineage suggests potential stealthy viral strategies in immune evasion

RY Neches, NC Kyrpides, CA Ouzounis - MBio, 2021 - Am Soc Microbiol
Orf8, one of the most puzzling genes in the SARS lineage of coronaviruses, marks a unique
and striking difference in genome organization between SARS-CoV-2 and SARS-CoV-1 …

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Y Zhang, Y Chen, Y Li, F Huang… - Proceedings of the …, 2021 - National Acad Sciences
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
become a global pandemic and has claimed over 2 million lives worldwide. Although the …

[HTML][HTML] The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Y Ren, T Shu, DI Wu, J Mu, C Wang, M Huang… - Cellular & molecular …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the ongoing
pandemic of Coronavirus Disease 2019. SARS-CoV-2 belongs to the genus …

[HTML][HTML] SARS-CoV-2 accessory protein ORF8 decreases antibody-dependent cellular cytotoxicity

G Beaudoin-Bussières, A Arduini, C Bourassa… - Viruses, 2022 - mdpi.com
Viruses use many different strategies to evade host immune responses. In the case of SARS-
CoV-2, its Spike mutates rapidly to escape from neutralizing antibodies. In addition to this …

SARS-CoV-2 ORF9c is a membrane-associated protein that suppresses antiviral responses in cells

A Dominguez Andres, Y Feng, AR Campos, J Yin… - BioRxiv, 2020 - biorxiv.org
Disrupted antiviral immune responses are associated with severe COVID-19, the disease
caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of …

[HTML][HTML] SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

H Jiang, H Zhang, Q Meng, J Xie, Y Li… - Cellular & molecular …, 2020 - nature.com
COVID-19 is caused by SARS-CoV-2. 1 As of July 16th, 2020, there were 13,579,581
diagnosed cases and 584,782 deaths attributed to COVID-19 reported globally …