Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering

C Ling, GL Peabody, D Salvachúa, YM Kim… - Nature …, 2022 - nature.com
Muconic acid is a bioprivileged molecule that can be converted into direct replacement
chemicals for incumbent petrochemicals and performance-advantaged bioproducts. In this …

Engineering glucose metabolism for enhanced muconic acid production in Pseudomonas putida KT2440

GJ Bentley, N Narayanan, RK Jha, D Salvachúa… - Metabolic …, 2020 - Elsevier
Pseudomonas putida KT2440 has received increasing attention as an important biocatalyst
for the conversion of diverse carbon sources to multiple products, including the olefinic …

Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity

CW Johnson, D Salvachúa, P Khanna, H Smith… - Metabolic engineering …, 2016 - Elsevier
The conversion of biomass-derived sugars and aromatic molecules to cis, cis-muconic acid
(referred to hereafter as muconic acid or muconate) has been of recent interest owing to its …

A novel muconic acid biosynthesis approach by shunting tryptophan biosynthesis via anthranilate

X Sun, Y Lin, Q Huang, Q Yuan… - Applied and environmental …, 2013 - Am Soc Microbiol
Muconic acid is the synthetic precursor of adipic acid, and the latter is an important platform
chemical that can be used for the production of nylon-6, 6 and polyurethane. Currently, the …

Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate

R Fujiwara, S Noda, T Tanaka, A Kondo - Nature Communications, 2020 - nature.com
Glucose and xylose are the major components of lignocellulose. Effective utilization of both
sugars can improve the efficiency of bioproduction. Here, we report a method termed …

Metabolic engineering of muconic acid production in Saccharomyces cerevisiae

KA Curran, JM Leavitt, AS Karim, HS Alper - Metabolic engineering, 2013 - Elsevier
The dicarboxylic acid muconic acid has garnered significant interest due to its potential use
as a platform chemical for the production of several valuable consumer bio-plastics …

Glucose-Free cis,cis-Muconic Acid Production via New Metabolic Designs Corresponding to the Heterogeneity of Lignin

T Sonoki, K Takahashi, H Sugita… - ACS Sustainable …, 2018 - ACS Publications
Lignin conversion to value-added products is one of the most attractive challenges to
develop a complete system for lignocellulosic biomass utilization. The objective of this study …

Biosensor‐Enabled Directed Evolution to Improve Muconic Acid Production in Saccharomyces cerevisiae

JM Leavitt, JM Wagner, CC Tu, A Tong… - Biotechnology …, 2017 - Wiley Online Library
Muconic acid is a valuable platform chemical with potential applications in the production of
polymers such as nylon and polyethylene terephthalate (PET). The conjugate base …

Bioprocess development for muconic acid production from aromatic compounds and lignin

D Salvachúa, CW Johnson, CA Singer, H Rohrer… - Green …, 2018 - pubs.rsc.org
Muconic acid (MA) is a bio-based platform chemical that can be converted into the
commodity petrochemical building blocks adipic acid or terephthalic acid, or used in …

Extending shikimate pathway for the production of muconic acid and its precursor salicylic acid in Escherichia coli

Y Lin, X Sun, Q Yuan, Y Yan - Metabolic engineering, 2014 - Elsevier
Abstract cis, cis-Muconic acid (MA) and salicylic acid (SA) are naturally-occurring organic
acids having great commercial value. MA is a potential platform chemical for the …