The concept of treating solid tumors by inhibiting tumor angiogenesis was first articulated
almost 30 years ago. For the next 10 years it attracted little scientific interest. This situation …

Angiogenesis is the process by which new blood vessels are formed from preexisting
microvasculature. To ensure an adequate blood supply, tumor cells release angiogenic …

Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

It has been recognized for decades that angiogenesis is an important event in tumor growth
and metastasis; the concept of the “angiogenic switch,” whereby tumors acquire the ability to …

The idea of antiangiogenic therapy was the brainchild of D r. J udah F olkman in the early
1970s. He proposed that by cutting off the blood supply, cancer cells would be deprived of …

Angiogenesis–the formation of new blood vessels within a tumor (or many other tissue
types)–has become a hotbed of pharmacological research as well as industrial drug …

A number of anti-angiogenesis drugs have been FDA-approved and are being used in
cancer treatment, and a number of other agents are in different stages of clinical …

Angiogenesis is regulated by the balance of pro-angiogenic factors and angiogenesis
inhibitors, and the imbalance of these regulators is the cause of pathological angiogenesis …

The formation of new blood vessels (angiogenesis) is crucial for the growth and persistence
of primary solid tumors and their metastases. Furthermore, angiogenesis is also required for …

Angiogenesis is essential for progressive solid tumor growth and thus constitutes a very
promising therapeutic target. Recent developments in understanding of the molecular …