The induction of neoangiogenesis is a critical step already present at the early stages of
tumor development and dissemination. The progressive identification of molecules playing a …

Besides antibodies against VEGF, that interfere with VEGF to block the angiogenic signaling
chain, several other strategies have been developed to interfere with VEGF signal …

It has been nearly 9years since the FDA (Food and Drug Administration) approved the first
anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other …

Deregulated angiogenesis has been identified as a key contributor in a number of
pathological conditions including cancer. It is a complex process, which involves highly …

Etiological concepts on cancer development, malignant growth and tumour propagation
have undergone a revolutionary development during recent years: Among other aspects, the …

Formation of new blood vessels in tumors, a process termed tumor angiogenesis, is a crucial
step during oncogenic progression. Blocking tumor angiogenesis is therefore expected to …

Angiogenesis, a process of new blood vessel formation, is a prerequisite for tumour growth
to supply the proliferating tumour with oxygen and nutrients. The angiogenic process may …

Blood supply is essential for development and growth of tumors and angiogenesis is the
fundamental process of new blood vessel formation from preexisting ones. Angiogenesis is …

Since 2004, four antiangiogenic drugs have been approved for clinical use in patients with
advanced solid cancers, on the basis of their capacity to improve survival in phase III clinical …

Targeting the tumor vasculature to “starve a tumor to death” instead of targeting tumor cells
with chemotherapeutic drugs was conceived over four decades ago and has led to the …