Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Within three decades, anti-angiogenic therapy has rapidly evolved into an integral
component of current standard anti-cancer treatment. Anti-angiogenic therapy has fulfilled a …

Tumor cells cannot grow as a mass above 2 to 3 mm3 because diffusion is insufficient for
oxygen and glucose requirements, unless the tumor induces a blood supply. This …

A vast amount of data shows that angiogenesis has a pivotal role in tumor growth,
progression, invasiveness and metastasis. This is a complex process involving essential …

Compelling data implicate angiogenesis and tumor-associated neovascularization as a
central pathogenic step in the process of tumor growth, invasion, and metastasis. These …

Tumor angiogenesis—new drugs on the block | Nature Biotechnology Skip to main content
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The critical role of angiogenesis in tumour growth and metastasis is now well established in
the literature. Growing tumours stimulate neovascularisation through the secretion of pro …

Publisher Summary As normal cells progress to tumorigenicity, they must develop two
distinct new characteristics not possessed by the normal cells from which they arise: they …

Advances in molecular biology have permitted the characterisation of mechanisms
underlying angiogenesis. Angiogenesis is a crucial process in tumour pathogenesis as it …

Advances in our comprehension of cancer biology and metastasis formation have led to the
development of new therapeutic approaches that target tumor biology. The survival and …