Allostatic load (AL) refers to prolonged dysregulation related to chronic stress that affects
brain regions such as the hippocampus, amygdala, and prefrontal cortex (PFC). Higher …

Introduction Despite the understanding of allostatic load (AL) as a consequence of ongoing
adaptation to stress, studies of the stress–AL association generally focus on a narrow …

Multiple biological processes are related to cognitive impairment in older adults, but their
combined impact on cognition in midlife is not known. Using an array of measurements …

Background Indices quantifying allostatic load (AL) and biological aging (BA) have
independently received widespread use in epidemiological literature. However, little …

Brain tissue deterioration is a significant contributor to lower cognitive ability in later life;
however, few studies have appropriate data to establish how much influence prior brain …

The allostatic load model has been used to quantify the physiological costs of the body's
response to repeated stressful demands and may provide a useful, integrative perspective …

The theory of allostatic load [McEwen, BS, Stellar, E., 1993. Stress and the individual:
mechanisms leading to disease. Arch. Intern. Med. 153, 2093–2101] describes how the …

Sažetak Mortality rates continue to decline among post-reproductive individuals. This makes
understanding long-term physiological responses to stress increasingly important. Allostatic …

OBJECTIVES: To examine the association between allostatic load (AL), an index of
multisystem physiological dysregulation, and frailty development over a 3‐year follow‐up in …

Early-onset Alzheimer's disease (EOAD) has been shown to progress more rapidly than late-
onset Alzheimer's disease (LOAD). However, no studies have compared the topography of …