Natural killer (NK) cells must be able to eliminate infected and transformed cells while
remaining tolerant of normal cells. NK-cell self-tolerance is thought to be maintained by self …

It is widely believed that self-tolerance of natural killer (NK) cells occurs because each NK
cell expresses at least one inhibitory receptor specific for a host major histocompatibility …

A fundamental tenet of the immune system is the requirement for lymphocytes to respond to
transformed or infected cells while remaining tolerant of normal cells. Natural killer (NK) cells …

The killing activity of NK cells is carried out by several activating NK receptors, which
includes NKp46, NKp44, NKp30, NKp80, NKG2D, and 2B4. The ligands of these receptors …

Natural killer (NK) cell tolerance mechanisms are incompletely understood. One possibility
is that they possess self-specific activation receptors that result in hyporesponsiveness …

Class I-specific stimulatory and inhibitory receptors expressed by NK cell subsets contribute
to the alloreactive potential of the self-tolerant murine NK cell repertoire. In this report, we …

Natural killer cells express inhibitory receptors specific for polymorphic MHC molecules,
which enables them to mediate “missing self recognition”, the capacity to attack self cells that …

Abstract TAP1−/−, β2‐microglobulin (β2m)−/− and TAP1/β2m−/− mice all express low but
quantitatively different levels of MHC class I molecules. Using these mice, we have …

Natural killer (NK) cells provide innate defense against tumors and infections by virtue of
potent capacities to immediately kill cellular targets and produce cytokines. These effector …

NK cell tolerance: revisiting the central dogma | Nature Immunology Skip to main content Thank
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