Since the emergence of regenerative medicine and tissue engineering more than half a
century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (> …

Vascularization is a leading limitation for the clinical application of in vitro engineered tissue
constructs because of the insufficient blood supply in the initial phase after implantation. In …

The hierarchical network of blood vessels comprises the larger vessels (veins and arteries),
the smaller ones (venules and arterioles), and the thinnest capillaries. The proper …

Over the past several decades, there has been an ever-increasing demand for organ
transplants. However, there is a severe shortage of donor organs, and as a result of the …

With a limited supply of organ donors and available organs for transplantation, the aim of
tissue engineering with three-dimensional (3D) bioprinting technology is to construct fully …

There has been an increasing demand for bioengineered blood vessels for utilization in
both regenerative medicine and drug screening. However, the availability of a true …

Artificial blood vessels composed of viable tissue represent the ideal vascular graft.
Compliance, lack of thrombogenicity, and resistance to infections as well as the ability to …

Current clinical treatment strategies for the bypassing of small diameter (< 6 mm) blood
vessels in the management of cardiovascular disease frequently fail due to a lack of suitable …

The fields of vascular biology and vascular medicine are so intertwined that advances in one
predict, explain, or are required for progress in the other. Bypass grafting, which once served …

Tissue engineering is an emerging means for resolving the problems of tissue repair and
organ replacement in regenerative medicine. Insufficient supply of nutrients and oxygen to …