OBJECTIVE. To compare the efficacy of inhaled corticosteroids in infants and preschoolers
with recurrent wheezing or asthma. METHODS. Randomized, prospective, controlled trials …

Background We hypothesized that asthma is preceded by a stage of recurrent episodes of
wheezing during the first years of life and that inhaled corticosteroid therapy during …

Rationale Systemic corticosteroids (SCS) are used for treat preschoolers with acute asthma
or wheezing exacerbations, with conflicting results. Objective To evaluate the effectiveness …

Background Inhaled corticosteroids (ICS) are the first‐line treatment for children with
persistent asthma. Their potential for growth suppression remains a matter of concern for …

OBJECTIVE. To review the use of inhaled corticosteroids on asthma control in children by
using the new therapeutic paradigm outlined in the Expert Panel Report 3: Guidelines for the …

Background Most international asthma guidelines recommend that children≤ 5 years with
asthma or recurrent wheezing be treated with daily low‐moderate dose inhaled …

Background It is unknown whether inhaled corticosteroids can modify the subsequent
development of asthma in preschool children at high risk for asthma. Methods We randomly …

BACKGROUND: Maintenance inhaled corticosteroid (ICS) therapy in preschool children
with recurrent wheezing at high-risk for development of asthma produces multiple clinical …

Accumulating evidence indicates that there are at least two phenotypes of wheezing in
preschool years with distinct natural history. Frequent wheezing in the first 3 years of life with …

Background Treatment guidelines for asthma recommend inhaled corticosteroids (ICS) as
first‐line therapy for children with persistent asthma. Although ICS treatment is generally …