Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in primates
RG Andrews, GH Knitter, SH Bartelmez, KE Langley… - 1991 - ashpublications.org
Recombinant human stem cell factor (SCF) is homologous with recombinant rat SCF (rrSCF)
and is a ligand for c-kit. We determined the influence of SCF on hematopoiesis in vitro and in …
and is a ligand for c-kit. We determined the influence of SCF on hematopoiesis in vitro and in …
A c-kit ligand, recombinant human stem cell factor, mediates reversible expansion of multiple CD34+ colony-forming cell types in blood and marrow of baboons
RG Andrews, SH Bartelmez, GH Knitter, D Myerson… - 1992 - ashpublications.org
The ligand for the human c-kit, recombinant human stem cell factor (SCF), was administered
to baboons at doses of 200, 100, 50, 25, and 10 micrograms/kg/d. SCF induced a dose …
to baboons at doses of 200, 100, 50, 25, and 10 micrograms/kg/d. SCF induced a dose …
Canine stem cell factor (c-kit ligand) supports the survival of hematopoietic progenitors in long-term canine marrow culture.
RM Shull, SV Suggs, KE Langley, KH Okino… - Experimental …, 1992 - europepmc.org
The cDNA for canine stem cell factor (cSCF, c-kit ligand) was cloned and expressed in
Escherichia coli. The recombinant protein (rcSCF), 165 amino acids in length, is very similar …
Escherichia coli. The recombinant protein (rcSCF), 165 amino acids in length, is very similar …
Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen
VC Broudy, NL Lin, GV Priestley, K Nocka, NS Wolf - 1996 - ashpublications.org
The phenotypes of mice that harbor a defect in the genes encoding either stem cell factor
(SCF) or its receptor, c-kit, indicate that this ligand/receptor pair is necessary for …
(SCF) or its receptor, c-kit, indicate that this ligand/receptor pair is necessary for …
The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony …
G Molineux, A Migdalska, M Szmitkowski, K Zsebo… - 1991 - ashpublications.org
Stem cell factor (SCF) is the ligand for the receptor encoded by the c-kit proto-oncogene.
Mutations of either c-kit or the SCF gene are responsible for the defects of W and SI mutant …
Mutations of either c-kit or the SCF gene are responsible for the defects of W and SI mutant …
Soluble c-kit receptor blocks stem cell factor bioactivity in vitro
DD Dahlen, NL Lin, YC Liu, VC Broudy - Leukemia research, 2001 - Elsevier
Stem cell factor (SCF) is a growth factor that promotes the survival, proliferation, and
differentiation of hematopoietic cells. SCF and its receptor, Kit, are normally present in both …
differentiation of hematopoietic cells. SCF and its receptor, Kit, are normally present in both …
The in vitro and in vivo effects of stem cell factor on human hematopoiesis
R Hoffman, J Tong, J Brandt, C Traycoff, E Bruno… - Stem …, 1993 - Wiley Online Library
The c‐kit ligand or stem cell factor (SCF) and the c‐kit ligand receptor (KR) are thought to
play pivotal roles in the regulation of human hematopoiesis. When added to interleukin 3 (IL …
play pivotal roles in the regulation of human hematopoiesis. When added to interleukin 3 (IL …
Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit
K Tsuji, KM Zsebo, M Ogawa - 1991 - ashpublications.org
Mice with W mutations characterized by hypopigmentation, sterility, anemia, and mast cell
deficiency have abnormalities in c-kit, a receptor with tyrosine kinase activity. Recently, the …
deficiency have abnormalities in c-kit, a receptor with tyrosine kinase activity. Recently, the …
Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule
S Okada, H Nakauchi, K Nagayoshi, S Nishikawa… - 1991 - ashpublications.org
The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor for stem cell
factor (SCF). The c-kit/SCF signal is expected to have an important role in hematopoiesis. A …
factor (SCF). The c-kit/SCF signal is expected to have an important role in hematopoiesis. A …
Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing …
JV Matous, K Langley, K Kaushansky - 1996 - ashpublications.org
Although much is now known about the biological properties of the c-kit receptor and its
ligand, stem cell factor (SCF), little is known of the structural basis for the binding and …
ligand, stem cell factor (SCF), little is known of the structural basis for the binding and …