The present study has assessed the relationship between formalin-induced nociception and
formalin-induced inflammation by comparing the dose-related effects of anti-inflammatory …

The effect of different formalin concentrations on the nociceptive response in the formalin
test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of …

The formalin test in mice is a valid and reliable model of nociception and is sensitive for
various classes of analgesic drugs. The noxious stimulus is an injection of dilute formalin …

Formalin (0.25, 0.5, 3, and 5%) injected into the knee joint of rats induced a dose-dependent
nociception that was featured by 2 phases of intense guarding behavior of the affected limb …

The formalin test is used as a primary behavioural screen for assaying the antinociceptive
activity of compounds in laboratory rodents. After hindpaw formalin injection, nociceptive …

The formalin test is a well‐established model for assessing nociceptive processes and
analgesic drug effects. Previous studies have provided statistical validation of optimal …

Subcutaneous formalin injection is widely used as a nociceptive stimulus in the rat. This
procedure evokes overt behaviors that last about 90 minutes. However, little is known about …

The formalin test was introduced as a model of tonic pain in 1977, and has since been used
extensively in rats and mice. In rats, formalin generates an initial phase of activity (5–10 min …

The orofacial formalin test in the rat is a valid and reliable model of nociception and is
sensitive to various classes of analgesic drugs. The noxious stimulus consists in an injection …

Injection of formalin into a hind paw of rats produces localized inflammation and pain. The
nociceptive effect of formalin, recorded as flinching/shaking of the injected paw, is biphasic …