A new theory of carcinogenesis is presented. It is based on the premise that the initial step in
the development of cancer is injury by a carcinogen of the coding units in the specialized …

The precise mechanism (s) whereby normal cells become malignant are not known with any
degree of certainty. However, many mechanisms have been proposed on the basis of …

The following analysis will be based on several major assumptions: namely, carcinogenesis,
in the main, can be conceptualized by the initiationipromotion concept (1-4); and the …

In recent years several reviews have been published about our present knowledge of the
most fundamental problem in basic cancer research, viz., that of carcinogenesis (28, 43, 59 …

Dr. Creech, fellow members, and guests, I would like to take this opportunity to thank you for
the honor of being your president for the past year. It has been a year of mixed blessings for …

The prevention and cure of cancer has been one of the great goals of medical science for
many years. Although only partial success can yet be claimed, intensive research on an …

Until now cancerogenesis has been studied in close relation with the corresponding
malignant phenotype. Such unified approach defines cancer as uncontrolled cellular …

A concept of neoplasms, based upon developmental and oncological principles, states that
carcinomas are caricatures of tissue renewal, in that they are composed of a mixture of …

(Pharmaceuticals Division) Alderley Park, Macclesfield, Cheshire THE number of
substances known to cause tumours when given by one route or another to animals of one …

Publisher Summary This chapter distinguishes tumor etiology (concerned with the
carcinogenic agents themselves, their chemical interrelationships, and their physical and …