The κ opioid receptor and food intake

JE Morley, AS Levine, J Kneip, M Grace… - European journal of …, 1985 - Elsevier
Many studies have suggested a role of opioid receptors in the modulation of food intake.
Several distinct classes of opioid receptors have been postulated. In an attempt to establish …

Reward systems and food intake: role of opioids

BA Gosnell, AS Levine - International journal of obesity, 2009 - nature.com
Humans eat for many reasons, including the rewarding qualities of foods. A host of
neurotransmitters have been shown to influence eating behavior and some of these appear …

Mu‐opioid receptor knockout mice show diminished food‐anticipatory activity

MJH Kas, R Van Den Bos, AM Baars… - European Journal of …, 2004 - Wiley Online Library
We have previously suggested that during or prior to activation of anticipatory behaviour to a
coming reward, µ‐opioid receptors are activated. To test this hypothesis schedule induced …

Reversible suppression of food reward behavior by chronic mu-opioid receptor antagonism in the nucleus accumbens

AC Shin, PJ Pistell, CB Phifer, HR Berthoud - Neuroscience, 2010 - Elsevier
Overindulgence in easily available energy-dense palatable foods is thought to be an
important factor in the current obesity epidemic but the underlying neural mechanisms are …

Diet-induced obesity increases μ opioid receptor binding in specific regions of the rat brain

SL Smith, JA Harrold, G Williams - Brain research, 2002 - Elsevier
Mu (μ) opioid agonists preferentially increase the intake of highly palatable food. Here we
investigated changes in μ opioid binding in feeding-and reward-related brain regions in rats …

Endogenous opioid modulation of food intake and body weight: Implications for opioid influences upon motivation and addiction

RJ Bodnar - Peptides, 2019 - Elsevier
This review is part of a special issue dedicated to Opioid addiction, and examines the
influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake …

Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food

P Cottone, V Sabino, L Steardo… - …, 2008 - nature.com
Binge eating and an increased role for palatability in determining food intake are abnormal
adaptations in feeding behavior linked to eating disorders and body weight dysregulation …

Induction of hyperphagia and carbohydrate intake by μ-opioid receptor stimulation in circumscribed regions of frontal cortex

JD Mena, K Sadeghian, BA Baldo - Journal of Neuroscience, 2011 - Soc Neuroscience
Frontal cortical regions are activated by food-associated stimuli, and this activation appears
to be dysregulated in individuals with eating disorders. Nevertheless, frontal control of basic …

Decreased consumption of sweet fluids in mu opioid receptor knockout mice: a microstructural analysis of licking behavior

SB Ostlund, A Kosheleff, NT Maidment… - Psychopharmacology, 2013 - Springer
Rationale Evidence suggests that the palatability of food (ie, the hedonic impact produced
by its sensory features) can promote feeding and may underlie compulsive eating, leading to …

Opioids as facilitators of feeding: can any food be rewarding?

PK Olszewski, J Alsiö, HB Schiöth, AS Levine - Physiology & behavior, 2011 - Elsevier
Palatability is one of the most rewarding aspects of consummatory behavior. Opioids, potent
facilitators of intake of sweet and fat tastants, are thought to mediate hedonics of feeding …