Transplantation of pancreatic islets reconstitutes glucose homeostasis in diabetes mellitus.
Before transplantation, islets are disrupted from the surrounding blood vessels by the …

Islet transplantation has become a widely accepted therapeutic option for selected patients
with type 1 diabetes mellitus. However, in order to achieve insulin independence a great …

Pancreatic islet transplantation has emerged as a therapy for type 1 diabetes and is today
performed using both freshly isolated and cultured islets. Islet blood vessels are disrupted …

Pancreatic islet transplantation is an emerging therapy for type 1 diabetes. To survive and
function, transplanted islets must revascularize because islet isolation severs arterial and …

An adequate revascularization is crucial for islet survival and function after transplantation.
Previous studies have suggested that islet revascularization is concluded within 14 days …

OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet
endothelial cells (ECs), which can contribute to the formation of functional blood vessels …

Abstract Background/Aims: An important reason for the large amount of islets required for
successful islet transplantation is likely to be inadequate engraftment of the transplanted …

Transplantation of isolated islets of Langerhans is frequently followed by early loss of islet
function. Because whether this is caused by insufficient vascularization or graft rejection is …

The formation of a new microvasculature is essential for the long-term survival and function
of the islet graft. In this study we examined endothelium of isolated pancreatic islets by …

Although pancreatic islets comprise only 1–2% of pancreatic mass, they receive 5–10% of
pancreatic blood flow. Blood vessels within pancreatic islets are of a greater density than …