Endogenous pancreatic islets have a dense glomerular-like angioarchitecture, which
ensures an optimal delivery of oxygen and nutrients to the islet cells, provides signals from …

Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …

OBJECTIVE—Engraftment and function of human islet cell implants is considered to be
dependent on their rapid and adequate revascularization. Studies with rodent islet grafts …

In pancreatic islet transplantation, revascularization is crucial for the graft's survival and
function. In this study, the endothelium of isolated islets and revascularization and function of …

Transplantation of isolated islets of Langerhans in diabetic patients is frequently followed by
an early loss of function due to acute rejection. Since the primary target of host-vs-graft …

Although the microvascular endothelium has been identified as the primary target site for the
initiation of pancreatic islet graft rejection, little is known of the microvascular and cellular …

Microvascular development is determined by the interplay between tissue cells and
microvascular endothelial cells. Because the pancreatic islet is an organ composed mainly …

Pancreatic islet transplantation is a promising therapy to regain glycemic control in diabetic
patients. The selection of ideal grafts is the basis to guarantee short‐term effectivity and …

Aims/hypothesis Highly blood-perfused islets have been observed to be the most functional
islets in the native pancreas. We hypothesised that differences in vascular support of islets in …

Experimental studies indicate low revascularization of intraportally transplanted islets. This
study aimed to quantify, for the first time, the blood perfusion of intrahepatically transplanted …