A large proportion of islets are lost after transplantation partly due to a lack of functional
vasculature. Islets revascularize from host tissue but the process takes up to 2 weeks and …

We have reported that vascular endothelial growth factor (VEGF) promotes the
revascularization of transplanted islets, thereby reducing the initial number required to …

To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic …

The major feature of the human pancreatic islet architecture is the organization of endocrine
cells into clusters comprising central β cells and peripheral α cells surrounded by …

The concept of pancreatic β-cell mass is fundamental to the understanding of normal
metabolism, the pathogenesis of diabetes, and the transplantation of β-cell tissue. The …

Objective To review the current progress of islet cell transplantation in patients with insulin-
dependent diabetes, emphasizing on the difficulties with recovering and preserving islet cell …

A considerable number of experimental studies have demonstrated that the reestablishment
of an appropriate microvascular supply is an essential prerequisite for successful pancreatic …

We have developed a chamber model of islet engraftment that optimizes islet survival by
rapidly restoring islet-extracellular matrix relationships and vascularization. Our aim was to …

Endothelial progenitor cells (EPCs) have been shown to be involved in vascular
regeneration and angiogenesis in experimental diabetes. Because insulin therapy mobilizes …

Lack of rapid revascularization and inflammatory attacks at the site of transplantation
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …