Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs

S Thakral, A Yadav, V Singh, M Kumar, P Kumar… - Ageing Research …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), also called senile dementia, is the most common
neurological disorder. Around 50 million people, mostly of advanced age, are suffering from …

Update on the pharmacological treatment of Alzheimer's disease

F Massoud, S Gauthier - Current neuropharmacology, 2010 - ingentaconnect.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Worldwide
prevalence of the disease is estimated at more than 24 million cases. With aging of …

Pharmacotherapy of Alzheimer's disease: Seeking clarity in a time of uncertainty

N Husna Ibrahim, MF Yahaya, W Mohamed… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is recognized as a major health hazard that mostly affects people
older than 60 years. AD is one of the biggest medical, economic, and social concerns to …

Pathophysiological aspects and therapeutic armamentarium of Alzheimer's disease: recent trends and future development

BP Dave, YB Shah, KG Maheshwari… - Cellular and Molecular …, 2023 - Springer
Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …

Developing effective Alzheimer's disease therapies: clinical experience and future directions

DR Elmaleh, MR Farlow, PS Conti… - Journal of …, 2019 - content.iospress.com
Alzheimer's disease (AD) clinical trials, focused on disease modifying drugs and conducted
in patients with mild to moderate AD, as well as prodromal (early) AD, have failed to reach …

Role of aducanumab in the treatment of Alzheimer's disease: Challenges and opportunities

M Vaz, V Silva, C Monteiro… - Clinical interventions in …, 2022 - Taylor & Francis
Aducanumab is a monoclonal antibody selective for amyloid β (Aβ) aggregates. In June
2021, aducanumab became the first drug underlying the pathophysiology of Alzheimer's …

New and emerging treatments for Alzheimer's disease

A Corbett, J Smith, C Ballard - Expert Review of Neurotherapeutics, 2012 - Taylor & Francis
Alzheimer's disease (AD) and other dementias represent a significant and increasing clinical
challenge. This review highlights current treatment options for AD and the main focusses of …

Alzheimer's disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?

K Mullane, M Williams - Biochemical pharmacology, 2020 - Elsevier
Alzheimer's Disease (AD) therapeutics based on the amyloid hypothesis have repeatedly
failed in clinical trials. Together with numerous reports that amyloid is present in brains from …

Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions

A Abeysinghe, R Deshapriya, C Udawatte - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder and is identified as the most
common cause for dementia. Despite huge global economic burden and the impact on the …

Recent developments in Alzheimer's disease therapeutics

MS Rafii, PS Aisen - BMC medicine, 2009 - Springer
Alzheimer's disease is a devastating neurological disorder that affects more than 37 million
people worldwide. The economic burden of Alzheimer's disease is massive; in the United …