[HTML][HTML] Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update

LK Huang, YC Kuan, HW Lin, CJ Hu - Journal of Biomedical Science, 2023 - Springer
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet
medical need worldwide. The pathogenesis of AD involves various pathophysiological …

Pharmacotherapies for Alzheimer's disease: beyond cholinesterase inhibitors

HO Tayeb, HD Yang, BH Price, FI Tarazi - Pharmacology & therapeutics, 2012 - Elsevier
Alzheimer's disease (AD) is the most common cause of memory impairment and dementia in
the elderly. AD is pathologically characterized by extracellular deposits of beta-amyloid (Aβ) …

[HTML][HTML] Current understanding of the physiopathology, diagnosis and therapeutic approach to Alzheimer's disease

V García-Morales, A González-Acedo… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. It is characterized by
cognitive decline and progressive memory loss. The aim of this review was to update the …

[HTML][HTML] “Aducanumab” making a comeback in Alzheimer's disease: An old wine in a new bottle

T Behl, I Kaur, A Sehgal, S Singh, N Sharma… - Biomedicine & …, 2022 - Elsevier
Despite presence of substantial evidence suggesting the pivotal role of amyloid (Aβ) in
Alzheimer's disease (AD), very few therapeutic agents have been able to ameliorate the …

Have there been improvements in Alzheimer's disease drug discovery over the past 5 years?

R Cacabelos - Expert opinion on drug discovery, 2018 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is the most important neurodegenerative disorder
with a global cost worldwide of over $700 billion. Pharmacological treatment accounts for 10 …

Therapies for prevention and treatment of Alzheimer's disease

J Mendiola-Precoma, LC Berumen… - BioMed research …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia associated with a
progressive neurodegenerative disorder, with a prevalence of 44 million people throughout …

[HTML][HTML] Recent advances in the neurobiology and neuropharmacology of Alzheimer's disease

K Kumar, A Kumar, RM Keegan… - Biomedicine & …, 2018 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
progressive deterioration of cognitive functions. The pathological hallmarks are extracellular …

[HTML][HTML] Natural products-based drugs: potential therapeutics against Alzheimer's disease and other neurological disorders

M Ayaz, F Ullah, A Sadiq, MO Kim, T Ali - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer's disease (AD) and dementia are disorders of the aging population and becoming
major health care burden worldwide due to unavailability of complete therapy. AD is the …

[HTML][HTML] Small-molecule theranostics in Alzheimer's disease

Á Sarabia-Vallejo, P López-Alvarado… - European Journal of …, 2023 - Elsevier
Alzheimer's Disease (AD) remains one of the most challenging health-related issues for our
society. It is becoming increasingly prevalent, especially in developed countries, due to the …