Signal transduction systems and atrial fibrillation

A Goette, U Lendeckel, HU Klein - Cardiovascular research, 2002 - academic.oup.com
Cell communication, an essential component of integrated physiological function in
multicellular organisms, is mediated largely through informational molecules, such as …

Atrial fibrillation: pathogenesis, predisposing factors, and genetics

M Sagris, EP Vardas, P Theofilis… - International journal of …, 2021 - mdpi.com
Atrial fibrillation (AF) is the most frequent arrhythmia managed in clinical practice, and it is
linked to an increased risk of death, stroke, and peripheral embolism. The Global Burden of …

Epigenetic mechanisms in atrial fibrillation: new insights and future directions

H Tao, KH Shi, JJ Yang, J Li - Trends in cardiovascular medicine, 2016 - Elsevier
Atrial fibrillation (AF) is the most common sustained arrhythmia. AF is a complex disease that
results from genetic and environmental factors and their interactions. In recent years …

Genetic basis of atrial fibrillation-on the road to precision medicine

S Kany, RB Schnabel - Herzschrittmachertherapie & …, 2023 - europepmc.org
Vorhofflimmern (VHF) ist eine verbreitete Herzkrankheit mit komplexer genetischer
Grundlage. Trotz der Fortschritte in der Behandlung bleibt die Sterblichkeit bei VHF …

Cellular electrophysiology and the substrate for atrial fibrillation

JR Ehrlich, P Coutu, YH Yeh, X Qi, S Nattel - Atrial Fibrillation: From Bench …, 2008 - Springer
This chapter focuses on basic cellular atrial electrophysiology and tries to pinpoint the
consequences of cardiac conditions that play a role in creating a substrate for atrial …

Genetic markers for risk management of atrial fibrillation, atrial flutter, and stroke

A Helgadottir, D Gudbjartsson - US Patent App. 14/153,926, 2014 - Google Patents
Cardiac arrhythmia is a group of medical conditions, in which the electrical activity of the
heart is irregular, or is slower or faster than normal. Some arrhythmias are life-threatening …

Atrial fibrillation: evidence for genetically determined disease

A Andalib, R Brugada, S Nattel - Current opinion in cardiology, 2008 - journals.lww.com
Rapidly evolving work indicates that there are important genetic determinants of atrial
fibrillation, and suggests that understanding these determinants will help us both to …

195 PR interval prolongation as intermediate phenotype for atrial fibrillation: Association with echocardiographic parameters and biomarkers (the LIFE-Adult-Study)

S Zeynalova, J Kornej, M Loeffler, S Tautenhahn… - EP …, 2018 - academic.oup.com
Purpose: In this study, we aimed to determine the specific impact of hypertension, type-2
diabetes mellitus (T2DM), and ageing on atrial molecular biology by using animal models of …

Atrial fibrillation—a new cardiac channelopathy

R Otway, JI Vandenberg, D Fatkin - Heart, Lung and Circulation, 2007 - Elsevier
Atrial fibrillation (AF) is a common complication of a wide range of cardiac and systemic
diseases and is regarded generally as a sporadic, acquired disorder. Familial clustering of …

Ventricularization of atrial gene expression in the fibrillating heart?

GF Tomaselli - Circulation research, 2005 - Am Heart Assoc
Structural and functional changes in the heart in re-sponse to disease or dysfunction are
essential compensatory responses to stress. In the context of sustained stress such initially …