Posttranslational control of HuR function

I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …

Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization

SD Volpe, R Listro, FA Ambrosio… - ACS Medicinal …, 2023 - ACS Publications
The RNA binding protein HuR regulates the post-transcriptional process of different
oncogenes and tumor suppressor genes, and its dysregulation is linked with cancer. Thus …

Identification of small-molecule inhibitors of the HuR/RNA interaction using a fluorescence polarization screening assay followed by NMR validation

Z Wang, A Bhattacharya, DN Ivanov - PloS one, 2015 - journals.plos.org
The human antigen R (HuR) stabilizes many mRNAs of proto-oncogene, transcription
factors, cytokines and growth factors by recognizing AU-rich elements (AREs) presented in …

HuR as therapeutic target in cancer: what the future holds

D Goutas, A Pergaris, C Giaginis… - Current Medicinal …, 2022 - ingentaconnect.com
ELAV-like protein 1 or HuR (human antigen R) is an RNA-binding protein that in humans is
encoded by the ELAVL1 gene, and one of its best functions is to stabilize mRNAs in order to …

Targeting the multifaceted HuR protein, benefits and caveats

C Zucal, V D'Agostino, R Loffredo, B Mantelli… - Current drug …, 2015 - ingentaconnect.com
The RNA-binding protein (RBP) HuR is one of the most widely studied regulators of the
eukaryotic posttranscriptional gene expression and it plays a physiological role in mediating …

Novel compounds targeting the RNA-binding protein HuR. structure-based design, synthesis, and interaction studies

S Della Volpe, R Nasti, M Queirolo… - ACS medicinal …, 2019 - ACS Publications
The key role of RNA-binding proteins (RBPs) in regulating post-transcriptional processes
and their involvement in several pathologies (ie, cancer and neurodegeneration) have …

Regulation of HuR structure and function by dihydrotanshinone-I

P Lal, L Cerofolini, VG D'Agostino, C Zucal… - Nucleic acids …, 2017 - academic.oup.com
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …

The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack

A Guha, S Waris, LB Nabors, N Filippova… - Advanced drug delivery …, 2022 - Elsevier
Glioblastoma (GBM) is a malignant and aggressive brain tumor with a median survival of∼
15 months. Resistance to treatment arises from the extensive cellular and molecular …

Cytoskeleton-dependent transport as a potential target for interfering with post-transcriptional HuR mRNA regulons

W Eberhardt, A Badawi, A Biyanee… - Frontiers in …, 2016 - frontiersin.org
The ubiquitous mRNA binding protein human antigen R (HuR), a member of the embryonal
lethal abnormal vision protein family has a critical impact on the post-transcriptional control …

[HTML][HTML] Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis

J Wang, Y Guo, H Chu, Y Guan, J Bi… - International journal of …, 2013 - mdpi.com
The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family
of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has …