Functional inhibition of the RNA‐binding protein HuR sensitizes triple‐negative breast cancer to chemotherapy
Chemotherapy remains the standard treatment for triple‐negative breast cancer (TNBC);
however, chemoresistance compromises its efficacy. The RNA‐binding protein Hu antigen R …
however, chemoresistance compromises its efficacy. The RNA‐binding protein Hu antigen R …
Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
NC Meisner, M Hintersteiner, K Mueller… - Nature chemical …, 2007 - nature.com
Careful regulation of mRNA half-lives is a fundamental mechanism allowing cells to quickly
respond to changing environmental conditions. The mRNA-binding Hu proteins are …
respond to changing environmental conditions. The mRNA-binding Hu proteins are …
The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer
Background The discordance between steady-state levels of mRNAs and protein has been
attributed to posttranscriptional control mechanisms affecting mRNA stability and translation …
attributed to posttranscriptional control mechanisms affecting mRNA stability and translation …
Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation
W Eberhardt, A Doller… - Current Protein and …, 2012 - ingentaconnect.com
The ubiquitous mRNA-binding protein human antigen R (HuR) and its neuronal relatives
(HuB, HuC, HuD) participate in the post-transcriptional regulation of many AU-rich element …
(HuB, HuC, HuD) participate in the post-transcriptional regulation of many AU-rich element …
Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2
A Badawi, S Hehlgans, J Pfeilschifter, F Rödel… - Cancer letters, 2017 - Elsevier
Increased abundance of the mRNA-binding protein human antigen R (HuR) is a
characteristic feature of many cancers and frequently associated with a high grade …
characteristic feature of many cancers and frequently associated with a high grade …
[HTML][HTML] Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder
HuR, an RNA-binding protein, post-transcriptionally regulates nearly 4% of encoding
proteins implicated in cell survival. Here we show that HuR is required for the efficacy of …
proteins implicated in cell survival. Here we show that HuR is required for the efficacy of …
[HTML][HTML] Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis
FF Blanco, R Preet, A Aguado, V Vishwakarma… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-
related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional …
related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional …
HuR thermal stability is dependent on domain binding and upon phosphorylation
RM Scheiba, Á Aroca, I Díaz-Moreno - European biophysics journal, 2012 - Springer
Human antigen R (HuR) is a multitasking RNA binding protein involved in
posttranscriptional regulation by recognizing adenine-and uracile-rich elements placed at …
posttranscriptional regulation by recognizing adenine-and uracile-rich elements placed at …
Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR
S Schulz, A Doller, NR Pendini, JA Wilce, J Pfeilschifter… - Cellular signalling, 2013 - Elsevier
The ubiquitous mRNA binding protein human antigen R (HuR) participates in the post-
transcriptional regulation of many AU-rich element (ARE)-bearing mRNAs. Previously, by …
transcriptional regulation of many AU-rich element (ARE)-bearing mRNAs. Previously, by …
Functional interplay between RNA-binding protein HuR and microRNAs
S Srikantan, K Tominaga… - Current Protein and …, 2012 - ingentaconnect.com
The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs
encoding proteins with roles in cell division, cell survival, immune response, and …
encoding proteins with roles in cell division, cell survival, immune response, and …