Human antigen R: A potential therapeutic target for liver diseases

R Liu, K Wu, Y Li, R Sun, X Li - Pharmacological Research, 2020 - Elsevier
Human antigen R (HuR), also known as HuA and embryonic lethal abnormal vision-like 1
(ELAVL1), is a ubiquitously expressed RNA binding protein and functions as an RNA …

Complex HuR function in pancreatic cancer cells

JR Brody, DA Dixon - Wiley Interdisciplinary Reviews: RNA, 2018 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with dismal
patient outcomes. The underlying core genetic drivers of disease have been identified in …

Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach

F Vasile, S Della Volpe, FA Ambrosio, G Costa… - SCiEntifiC …, 2018 - nature.com
Post-transcriptional processes have been recognised as pivotal in the control of gene
expression, and impairments in RNA processing are reported in several pathologies (ie …

RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage

W Dai, G Zhang, EV Makeyev - Nucleic acids research, 2012 - academic.oup.com
RNA-binding protein HuR modulates the stability and translational efficiency of messenger
RNAs (mRNAs) encoding essential components of the cellular proliferation, growth and …

[HTML][HTML] Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity

IL De Silanes, J Fan, CJ Galbán, RG Spencer… - Gene …, 2004 - ncbi.nlm.nih.gov
HuR, a protein that binds to target mRNAs and can enhance their stability and translation, is
increasingly recognized as a pivotal regulator of gene expression during cell division and …

[HTML][HTML] Dual mechanisms of action of the RNA-binding protein human antigen R explains its regulatory effect on melanoma cell migration

F Moradi, P Berglund, R Linnskog, K Leandersson… - Translational …, 2016 - Elsevier
Overexpression of wingless-type MMTV integration site family 5A (WNT5A) plays a
significant role in melanoma cancer progression; however, the mechanism (s) involved …

Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype

K Mazan-Mamczarz, PR Hagner, S Corl, S Srikantan… - Oncogene, 2008 - nature.com
In a breast tumor xenograft model, the MCT-1 oncogene increases the in vivo tumorgenicity
of MCF7 cells by promoting angiogenesis and inhibiting apoptosis. Increases in the tumor …

Loss of repression of HuR translation by miR‐16 may be responsible for the elevation of HuR in human breast carcinoma

F Xu, X Zhang, Y Lei, X Liu, Z Liu… - Journal of cellular …, 2010 - Wiley Online Library
Elevated levels of RNA binding protein HuR were found in various human cancers.
However, the mechanisms underlying HuR over‐expression in cancers have not been fully …

HuR's role in gemcitabine efficacy: an exception or opportunity?

JR Brody, GE Gonye - Wiley Interdisciplinary Reviews: RNA, 2011 - Wiley Online Library
Over the next few years, research teams will focus on, and millions of dollars will be spent
on, sorting through cancer genomes. Undoubtedly,'druggable'targets and events will be …

Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites

PJ Uren, SC Burns, J Ruan, KK Singh, AD Smith… - Journal of Biological …, 2011 - ASBMB
The ubiquitously expressed RNA-binding protein Hu antigen R (HuR) or ELAVL1 is
implicated in a variety of biological processes as well as being linked with a number of …