MicroRNAs and RNA-binding proteins exert regulation on> 60% of coding genes, yet
interplay between them is little studied. Canonical microRNA binding occurs by base-pairing …

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths
in the United States, whereas colorectal cancer is the third most common cancer. The RNA …

Both RNA-binding proteins (RBP) and miRNA play important roles in the regulation of
mRNA expression, often acting together to regulate a target mRNA. In some cases the RBP …

Immunohistochemical analysis of paired tumor and normal tissue specimens revealed that
the expression and cytoplasmic abundance of the RNA-binding protein HuR increased with …

Recent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA
processing machinery has revealed previously unknown roles of posttranscriptional …

RNA-binding protein HuR binds U-or AU-rich sequences in the 3′-untranslated regions of
target mRNAs, stabilizing them and/or modulating their translation. Given the links of HuR …

The elevated expressions of RNA-binding protein HuR and long noncoding HOX transcript
antisense RNA (HOTAIR) are observed in numerous cancers. And HuR often exerts its …

Hu-antigen R (HuR) is an RNA-binding posttranscriptional regulator that belongs to the
Hu/ELAV family. HuR expression levels are modulated by a variety of proteins, microRNAs …

HuR emerged as a posttranscriptional regulator of mRNAs involved in cellular control,
stress, and immunity but its role in governing such responses remains elusive. In this study …

HuR binds to AU-rich element–containing mRNA to protect them from rapid degradation.
Here, we show that knockdown of HuR changes the oncogenic properties of oral cancer …