Comprehensive metabolomic and proteomic analyses reveal candidate biomarkers and related metabolic networks in atrial fibrillation

J Zhou, L Sun, L Chen, S Liu, L Zhong, M Cui - Metabolomics, 2019 - Springer
Introduction Atrial fibrillation (AF) is an abnormal heart rhythm characterized by an irregular
beating of the atria and is associated with an increased risk of heart failure, dementia, and …

Comprehensive metabolomic characterization of atrial fibrillation

C Lu, C Liu, D Mei, M Yu, J Bai, X Bao… - Frontiers in …, 2022 - frontiersin.org
Background Using human humoral metabolomic profiling, we can discover the diagnostic
biomarkers and pathogenesis of disease. The specific characterization of atrial fibrillation …

Integration of proteomic and metabolomic characterization in atrial fibrillation-induced heart failure

H Zhang, L Wang, D Yin, Q Zhou, L Lv, Z Dong, Y Shi - BMC genomics, 2022 - Springer
Background The exact mechanism of atrial fibrillation (AF)-induced heart failure (HF)
remains unclear. Proteomics and metabolomics were integrated to in this study, as to …

Combinational biomarkers for atrial fibrillation derived from atrial appendage and plasma metabolomics analysis

S Lai, X Hua, R Gao, L Zeng, J Song, J Liu, J Zhang - Scientific reports, 2018 - nature.com
Atrial fibrillation (AF) is one of the most common types of arrhythmias and often leads to
clinical complications. The objectives of this study were to offer insights into the metabolites …

Metabolomic and proteomic analyses of persistent valvular atrial fibrillation and non-valvular atrial fibrillation

B Hu, W Ge, Y Wang, X Zhang, T Li, H Cui… - Frontiers in …, 2021 - frontiersin.org
Atrial fibrillation (AF) is an abnormal heart rhythm related to an increased risk of heart failure,
dementia, and stroke. The distinction between valvular and non-valvular AF remains a …

[HTML][HTML] Biomarkers and key pathways in atrial fibrillation associated with mitral valve disease identified by multi-omics study

MY Li, HX Chen, HT Hou, J Wang, XC Liu… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background Mitral valve disease (MVD)-associated atrial fibrillation (AF) is one of the most
common arrhythmias with an increased risk of thromboembolic events. This study aimed to …

New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation

J Kornej, VA Hanger, L Trinquart, D Ko… - Cardiovascular …, 2021 - academic.oup.com
Atrial fibrillation (AF) is a common cardiac arrhythmia leading to many adverse outcomes
and increased mortality. Yet the molecular mechanisms underlying AF remain largely …

Metabolic considerations in atrial fibrillation―mechanistic insights and therapeutic opportunities―

M Harada, J Melka, Y Sobue, S Nattel - Circulation Journal, 2017 - jstage.jst.go.jp
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice and is
associated with morbidity and mortality. Over the past 2 decades, there have been major …

Genomic and proteomic study of the inflammatory pathway in patients with atrial fibrillation and cardiometabolic syndrome

HA Itani, MA Jaffa, J Elias, M Sabra, P Zakka… - Frontiers in …, 2020 - frontiersin.org
Atrial fibrillation (AF) and cardiometabolic syndrome (CMS) have been linked to
inflammation and fibrosis. However, it is still unknown which inflammatory cytokines …

Multiomics analysis of genetics and epigenetics reveals pathogenesis and therapeutic targets for atrial fibrillation

L Liu, J Huang, B Wei, J Mo, Q Wei… - BioMed Research …, 2021 - Wiley Online Library
Objective. This study is aimed at understanding the molecular mechanisms and exploring
potential therapeutic targets for atrial fibrillation (AF) by multiomics analysis. Methods …