Urolithiasis, a complex multifactorial disease, results from interactions between
environmental and genetic factors. Epidemiological studies have shown the association of …

Kidney stone, one of the oldest known diseases, has plagued humans for centuries,
consistently imposing a heavy burden on patients and healthcare systems worldwide due to …

In 222 random spot urine specimens, the calcium concentration and calcium oxalate
saturation {DG (CaOx)} were significantly higher among stone formers than among non …

The prevention or cure of stone disease will be achieved only by identifying biochemical,
physiological and molecular mechanisms operating before the formation of a calculus. Yet …

Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic
stone events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) …

Urolithiasis is a condition in which stones are formed in the urinary tract and considered to
be one of the most common urological disorders, longstanding medical illnesses and …

OBJECTIVE: To analyze urinary uric acid stone matrix proteins (SMP) with mass
spectrometry (MS) to evaluate the mechanisms of uric acid stone formation. SMP plays an …

Epidemiologic aspects of urinary tract stone disease are presented as a background for
understanding of the clinical impact of this pathologic condition. The principles for and the …

The pathophysiology of urinary stone formation is complex, involving a combination of
metabolic, genetic, and environmental factors. Over the past decades, remarkable advances …

Approximately 1 million Americans develop a kidney stone each year and an estimated 12%
of the population forms a stone some time during their life. Innovations in the management of …