Although considerable evidence exists that spinal neurokinin1 receptors are involved in
central sensitization of nociception, recent evidence from knockout studies indicates that …

The role of endogenous neurokinin A in changes in the excitability of spinal neurons during
adjuvant-induced, peripheral inflammation was examined by determining the effect of a …

Although the tachykinins substance P (SP) and neurokinin A (NKA) are coreleased from
primary afferent nociceptors and act via neurokinin (NK) receptors, their differential effects in …

The neurokinin-1 receptor and its tachykinin neuropeptide ligand substance P are
associated with the mediation of nociception. Substance P released from primary afferent …

Latent sensitization is a model of chronic pain in which a persistent state of pain
hypersensitivity is suppressed by opioid receptors, as evidenced by the ability of opioid …

Substance P (SP) has been widely studied as a mediator of nociception. The release of SP
from primary afferent neurons is increased during nociception, and SP activates neurokinin …

In spinal cord neurons in anesthetized rats, the role of neurokinin A and neurokinin‐2
receptors in the processing of nociceptive information from the knee joint was studied. The …

Peripheral nerve injury is associated with hyperesthesia and increased neurokinin-1
receptor (NK-1) expression in the dorsal horn of the spinal cord. To test the hypothesis that …

Previous work has demonstrated that persistent nociception evokes increased neurokinin-1
receptor (NK-1) gene expression in the spinal cord dorsal horn of the rat within 2 h but has …

Discovery of the occurrence of neurokinin-1 (NK-1) receptor internalization in response to
agonist activation has provided researchers with a new tool for studying tachykinin actions …