Mitogen-activated protein kinases (such as Erk1/2) regulate phosphorylation of the
microtubule-associated protein tau and processing of the amyloid protein β, both events …

Given the critical role of mitogen-activated protein kinase (MAPK) pathways in regulating
cellular processes that are affected in Alzheimer's disease (AD), the importance of MAPKs in …

The abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) has been proposed
to involve the extracellular-signal-regulated protein kinase (ERK) of the mitogen-activated …

The serine/threonine phosphatase 2A (PP2A) has been implicated in the pathogenesis of
Alzheimer's disease (AD) due to its important role in regulating dephosphorylation of the …

Proline-directed kinases such as the mitogen-activated protein (MAP) kinases, cyclin-
dependent protein kinase 5 (CDK5) and glycogen synthase 3 (GSK3) have been implicated …

Alzheimer's disease is characterized by the deposition of intracellular aggregates of
hyperphosphorylated tau protein. Tau hyperphosphorylation has been attributed in part to …

Extracellular‐signal‐regulated kinase (ERK) has been implicated in the pathogenesis of
Alzheimer's disease (AD), but the upstream cascade leading to ERK activation has not been …

The hallmarks of sporadic Alzheimer's disease (AD) are extracellular amyloid deposits,
intracellular neurofibrillary tangles (NFTs), and neuronal death. Hyperphosphorylation of tau …

Abnormal tau phosphorylation and deposition in neurones and glial cells is one of the major
features in tau pathies. The present study examines the involvement of the Ras/MEK/ERK …

Abstract Characterization of the earliest neuropathologic features of Alzheimer disease (AD)
indicates that synaptic degeneration accompanied by tau hyperphosphorylation and …