Seizure forecasting and cyclic control of seizures

RE Stirling, MJ Cook, DB Grayden, PJ Karoly - Epilepsia, 2021 - Wiley Online Library
Epilepsy is a unique neurologic condition characterized by recurrent seizures, where
causes, underlying biomarkers, triggers, and patterns differ across individuals. The …

Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes

DN Anderson, CM Charlebois, EH Smith, TS Davis… - Brain, 2024 - academic.oup.com
In patients with drug-resistant epilepsy, electrical stimulation of the brain in response to
epileptiform activity can make seizures less frequent and debilitating. This therapy, known as …

Chronic electroencephalography in epilepsy with a responsive neurostimulation device: current status and future prospects

VR Rao - Expert Review of Medical Devices, 2021 - Taylor & Francis
Introduction Implanted neurostimulation devices are gaining traction as therapeutic options
for people with certain forms of drug-resistant focal epilepsy. Some of these devices enable …

The RNS System: brain-responsive neurostimulation for the treatment of epilepsy

B Jarosiewicz, M Morrell - Expert review of medical devices, 2021 - Taylor & Francis
Introduction: Epilepsy affects more than 1% of the US population, and over 30% of adults
with epilepsy do not respond to antiseizure medications without life-impacting medication …

Seizure prediction for therapeutic devices: A review

K Gadhoumi, JM Lina, F Mormann, J Gotman - Journal of neuroscience …, 2016 - Elsevier
Research in seizure prediction has come a long way since its debut almost 4 decades ago.
Early studies suffered methodological caveats leading to overoptimistic results and lack of …

The circadian profile of epilepsy improves seizure forecasting

PJ Karoly, H Ung, DB Grayden, L Kuhlmann, K Leyde… - Brain, 2017 - academic.oup.com
It is now established that epilepsy is characterized by periodic dynamics that increase
seizure likelihood at certain times of day, and which are highly patient-specific. However …

[HTML][HTML] Seizure forecasting using a novel sub-scalp ultra-long term EEG monitoring system

RE Stirling, MI Maturana, PJ Karoly, ES Nurse… - Frontiers in …, 2021 - frontiersin.org
Accurate identification of seizure activity, both clinical and subclinical, has important
implications in the management of epilepsy. Accurate recognition of seizure activity is …

Chance and risk in epilepsy

MO Baud, T Proix, VR Rao… - Current opinion in …, 2020 - journals.lww.com
The canonical randomness of seizures is being reconsidered in light of cycles of brain
activity discovered through chronic EEG. This paradigm shift motivates development of next …

Seizure prediction: science fiction or soon to become reality?

DR Freestone, PJ Karoly, ADH Peterson… - Current neurology and …, 2015 - Springer
This review highlights recent developments in the field of epileptic seizure prediction. We
argue that seizure prediction is possible; however, most previous attempts have used data …

[HTML][HTML] When do epileptic seizures really begin?

MJ McKeown, JO McNamara - Neuron, 2001 - cell.com
Epilepsy, a disorder characterized by recurrent seizures, is a common neurological problem,
affecting more than two million Americans and 1% of the population worldwide. Epileptic …