Renal cells are used in basic research, disease models, tissue engineering, drug screening,
and in vitro toxicology. In order to provide a reliable source of human renal cells, we …

The metanephric kidney is a mesodermal organ that develops as a result of reciprocal
interactions between the ureteric bud and the blastema. The generation of embryonic stem …

The kidney is formed from two tissue populations derived from the intermediate mesoderm,
the ureteric bud, and the metanephric mesenchyme. Metanephric mesenchyme is a …

A tissue stem cell should exhibit long-term self-renewal, clonogenicity and a capacity to
differentiate into the tissue of origin. Such a postnatal renal stem cell has not been formally …

The in vitro derivation of renal lineage progenitor cells is essential for renal cell therapy and
regeneration. Despite extensive studies in the past, a protocol for renal lineage induction …

The kidneys are formed during development from two distinct primordial tissues, the
metanephric mesenchyme and the ureteric bud. The metanephric mesenchyme develops …

Nephron progenitors in the embryonic kidney propagate while generating differentiated
nephrons. However, in mice, the progenitors terminally differentiate shortly after birth. Here …

Objectives: The role of stem cells in regenerative medicine is evolving rapidly. Here, we
describe the application, for kidney regeneration, of a novel non‐genetically modified stem …

Stem cells in the kidney. The kidney is derived from the ureteric bud and the
metanephrogenic mesenchyme, and these two progenitor cells differentiate into more than …

In this study we have shown that the papilla of the mouse kidney contains a population of
Pax2+ cells that are detectable from the early postnatal period through to adulthood …