Context.—The 2 chief pathways implicated in colorectal carcinogenesis, microsatellite
instability and chromosomal instability, are not present in 20% to 37% of cases. Objective …

We hypothesized that in a comprehensive analysis of colorectal carcinomas (CRC) the three
currently known major molecular mechanisms of carcinogenesis (ie, chromosomal …

Purpose: The aim of this study was to relate the CpG island methylator phenotype (CIMP;
characterized by extensive promoter hypermethylation) to cancer-specific survival in …

Abstract The BRAF V600E mutation has been associated with microsatellite instability and
the CpG island methylator phenotype (CIMP) in colon cancer. We evaluated a large …

The CpG island methylator phenotype (CIMP) in colorectal tumours can be recognized by an
increased frequency of aberrant methylation in a specific set of genomic loci. Because of the …

Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN)
are well‐characterised molecular features of sporadic colorectal cancers (CRCs). In addition …

Purpose: Aberrant promoter methylation and genomic instability occur frequently during
colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown …

The BRAF oncogene is mutated in 15% of sporadic colorectal cancers. Approximately half of
these BRAF mutant cancers demonstrate frequent frameshift mutations termed microsatellite …

Background A molecular classification of colorectal cancer has been proposed based on
microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and mutations in …

Although the presence of MLH1 methylation in microsatellite-unstable colorectal cancer
generally indicates involvement of the CpG island methylator phenotype (CIMP) in the …