[HTML][HTML] Distinct molecular profiles of skull bone marrow in health and neurological disorders

ZI Kolabas, LB Kuemmerle, R Perneczky, B Förstera… - Cell, 2023 - cell.com
The bone marrow in the skull is important for shaping immune responses in the brain and
meninges, but its molecular makeup among bones and relevance in human diseases …

Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation

ZI Kolabas, LB Kuemmerle, R Perneczky, B Förstera… - bioRxiv, 2021 - biorxiv.org
The meninges of the brain are an important component of neuroinflammatory response.
Diverse immune cells move from the calvaria marrow into the dura mater via recently …

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

F Herisson, V Frodermann, G Courties, D Rohde… - Nature …, 2018 - nature.com
Innate immune cells recruited to inflammatory sites have short life spans and originate from
the marrow, which is distributed throughout the long and flat bones. While bone marrow …

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

A Cugurra, T Mamuladze, J Rustenhoven, T Dykstra… - Science, 2021 - science.org
INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses

M Heming, AL Börsch, H Wiendl, G Meyer zu Hörste - Genome Medicine, 2022 - Springer
The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …

High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease

D Mrdjen, A Pavlovic, FJ Hartmann, B Schreiner… - Immunity, 2018 - cell.com
Individual reports suggest that the central nervous system (CNS) contains multiple immune
cell types with diverse roles in tissue homeostasis, immune defense, and neurological …

Impact of aging on meningeal gene expression

M Neutzner, C Kohler, S Frank, HE Killer… - Fluids and Barriers of …, 2023 - Springer
Background The three-layered meninges cover and protect the central nervous system and
form the interface between cerebrospinal fluid and the brain. They are host to a lymphatic …

The meningeal transcriptional response to traumatic brain injury and aging

AC Bolte, DA Shapiro, AB Dutta, WF Ma, KR Bruch… - Elife, 2023 - elifesciences.org
Emerging evidence suggests that the meningeal compartment plays instrumental roles in
various neurological disorders, however, we still lack fundamental knowledge about …

Traumatic brain injury induces an adaptive immune response in the meningeal transcriptome that is amplified by aging

RG Buenaventura, AC Harvey, MP Burns… - Frontiers in …, 2023 - frontiersin.org
Traumatic Brain Injury (TBI) is a major cause of disability and mortality, particularly among
the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain …

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

D Schafflick, CA Xu, M Hartlehnert, M Cole… - Nature …, 2020 - nature.com
Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …