[HTML][HTML] Distinct molecular profiles of skull bone marrow in health and neurological disorders
The bone marrow in the skull is important for shaping immune responses in the brain and
meninges, but its molecular makeup among bones and relevance in human diseases …
meninges, but its molecular makeup among bones and relevance in human diseases …
Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation
The meninges of the brain are an important component of neuroinflammatory response.
Diverse immune cells move from the calvaria marrow into the dura mater via recently …
Diverse immune cells move from the calvaria marrow into the dura mater via recently …
Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration
F Herisson, V Frodermann, G Courties, D Rohde… - Nature …, 2018 - nature.com
Innate immune cells recruited to inflammatory sites have short life spans and originate from
the marrow, which is distributed throughout the long and flat bones. While bone marrow …
the marrow, which is distributed throughout the long and flat bones. While bone marrow …
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …
immune functions. The diverse role of myeloid populations, including monocytes …
High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses
The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …
High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease
D Mrdjen, A Pavlovic, FJ Hartmann, B Schreiner… - Immunity, 2018 - cell.com
Individual reports suggest that the central nervous system (CNS) contains multiple immune
cell types with diverse roles in tissue homeostasis, immune defense, and neurological …
cell types with diverse roles in tissue homeostasis, immune defense, and neurological …
Impact of aging on meningeal gene expression
M Neutzner, C Kohler, S Frank, HE Killer… - Fluids and Barriers of …, 2023 - Springer
Background The three-layered meninges cover and protect the central nervous system and
form the interface between cerebrospinal fluid and the brain. They are host to a lymphatic …
form the interface between cerebrospinal fluid and the brain. They are host to a lymphatic …
The meningeal transcriptional response to traumatic brain injury and aging
Emerging evidence suggests that the meningeal compartment plays instrumental roles in
various neurological disorders, however, we still lack fundamental knowledge about …
various neurological disorders, however, we still lack fundamental knowledge about …
Traumatic brain injury induces an adaptive immune response in the meningeal transcriptome that is amplified by aging
Traumatic Brain Injury (TBI) is a major cause of disability and mortality, particularly among
the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain …
the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain …
Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
D Schafflick, CA Xu, M Hartlehnert, M Cole… - Nature …, 2020 - nature.com
Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …