Biochemically and Structurally Characterizing the ATP-Dependent Chromatin Remodeler SMARCAD1

JW Markert - 2021 - search.proquest.com
Maintaining chromatin structure is a complex and dynamic process. The ability to regulate
this is essential for appropriate DNA compaction, transcription, DNA-replication, and DNA …

Structure and function of the chromatin remodeler SMARCAD1 with its nucleosome substrate

J Markert, K Zhou, K Luger - bioRxiv, 2021 - biorxiv.org
The ATP-dependent chromatin remodeler SMARCAD1 acts on nucleosomes during DNA
repair and transcription, but despite its implication in disease, information on its structure …

SMARCAD1 is an ATP-dependent histone octamer exchange factor with de novo nucleosome assembly activity

J Markert, K Zhou, K Luger - Science Advances, 2021 - science.org
The adenosine 5′-triphosphate (ATP)–dependent chromatin remodeler SMARCAD1 acts
on nucleosomes during DNA replication, repair, and transcription, but despite its implication …

Some assembly required: structural and mechanistic studies of histone chaperones, nucleosome assembly factors and ATP dependent chromatin remodelers

K Luger, K Zhou, J Markert, Y Liu - The FASEB Journal, 2022 - Wiley Online Library
All eukaryotes organize their DNA into nucleosomes, consisting of an octamer of the four
core histone proteins H2A, H2B, H3, and H4, around which 147 base pairs of DNA are …

Identification of new tissue-specific interaction partners of chromatin remodelling ATPase Smarca5

Y Arishaka - 2024 - dspace.cuni.cz
The regulation of chromatin structure is fundamental to a wide range of cellular processes,
including transcriptional regulation, cell division, differentiation and DNA damage repair …

The conserved chromatin remodeler SMARCAD1 interacts with TFIIIC and architectural proteins in human and mouse

P Sachs, P Bergmaier, K Treutwein, JE Mermoud - Genes, 2023 - mdpi.com
In vertebrates, SMARCAD1 participates in transcriptional regulation, heterochromatin
maintenance, DNA repair, and replication. The molecular basis underlying its involvement in …

The double CUE domain of chromatin remodelling factor SMARCAD1

P West, P West - 2012 - ora.ox.ac.uk
ATP-dependent chromatin remodellers represent a class of proteins that restructure
chromatin through the action of a conserved helicase-like ATPase domain. Remodellers …

Regulation of ATP-dependent chromatin remodelers: accelerators/brakes, anchors and sensors

S Paul, B Bartholomew - Biochemical Society Transactions, 2018 - portlandpress.com
All ATP-dependent chromatin remodelers have a DNA translocase domain that moves along
double-stranded DNA when hydrolyzing ATP, which is the key action leading to DNA …

[HTML][HTML] Chromatin remodeling enzymes: taming the machines

CL Peterson - EMBO reports, 2002 - embopress.org
Members of the ATP‐dependent family of chromatin remodeling enzymes play key roles in
the regulation of transcription, development, DNA repair and cell cycle. Each of these …

The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities

BJ Manning, T Yusufzai - Journal of Biological Chemistry, 2017 - ASBMB
Proper chromatin regulation is central to genome function and maintenance. The group III
chromodomain–helicase–DNA-binding (CHD) family of ATP-dependent chromatin …