Aberrant crypt foci (ACF) in the colon of carcinogen-treated rodents are considered to be the
earliest hallmark of colon carcinogenesis. In the present study the relationship between a …

Foci of aberrant crypts (ACF) have been identified in the unsectioned methylene blue
stained rodent colons and hypothesized to represent precursor lesions of colon cancer. In …

The main objective of the present study was to sequentially analyze growth and
morphological characteristics of aberrant crypt foci (ACF) in the rat colon. Sprague-Dawley …

Previous studies are consistent with the hypothesis that aberrant crypt foci (ACF) could be
intermediate biomarkers in colorectal carcinogenesis. The present controlled experimental …

In an attempt to demonstrate the relationship between aberrant crypt foci (ACF) and
subsequent colonic neoplasms, we investigated the distribution of ACF in the …

Formation of aberrant crypt foci (ACF) in archived colon tissue from animals in a previous
study was examined. The animals were fed a semisynthetic casein‐based diet in which the …

Aberrant crypts are putative preneoplastic lesions that have been proposed as intermediate
biomarkers for colon cancer. The goals of these studies were to determine (i) if the colon …

We evaluated the role of aberrant crypt foci (ACF) as biomarkers of colon cancer by studying
the sequential development (6-28 weeks) from early lesion to tumor in the colon of …

Aberrant crypts are aggregates of single to multiple colonic crypts evidencing hallmarks of
dysplasia and may be the earliest detectable pathological lesions for colon cancer. The …

To shed light on the association of intestinal microflora with the development of colon
cancer, we studied the modifying effects of intestinal microflora on the occurrence of 1, 2 …