Chronic pain is a global problem affecting up to 20% of the world's population and has a
significant economic, social and personal cost to society. Sensory neurons of the dorsal root …

Use-dependent inhibitors of voltage-gated sodium channels (VGSC) are important
therapeutic tools for chronic pain management, but are limited by possible severe side …

Peripheral nerve injury is known to up-regulate the expression of rapidly-repriming Nav1. 3
sodium channel within first-order dorsal root ganglion neurons and second-order dorsal …

The present study investigated the effect of inhibiting the expression of Nav1. 8 (PN3/SNS)
sodium channels by an antisense oligodeoxynucleotide (ODN) on bladder nociceptive …

Key points Voltage‐gated sodium channels are critical for peripheral sensory neuron
transduction and have been implicated in a number of painful and painless disorders. The β …

Being maladaptive and frequently unresponsive to pharmacotherapy, chronic pain presents
a major unmet clinical need. While an intact central nervous system is required for conscious …

Voltage-gated sodium channel α-subunit (Nav) is the major determinant of neuronal
electrophysiological characters. In order to compare the composition of Navs among …

We have investigated the expression of TTX-sensitive (TTXs) and TTX-resistant (TTXr)
sodium channel subtypes following injury to the inferior alveolar nerve (IAN), in order to …

Nine voltage-gated sodium channels are expressed in complex patterns in mammalian
nerve and muscle. Three channels, Nav1. 7, Nav1. 8, and Nav1. 9, are expressed selectively …

Dorsal root ganglion neurons express a wide repertoire of sodium channels with different
properties. Here, we report the cloning from rat, dorsal root ganglia (DRG), cellular …