Recent pairwise meta-analysis including only double-blind, randomized placebo-controlled
trials (DBRPCTs) with an enrichment design in which individuals with MDD were stabilized …

Studies have found that up to two-thirds of patients with major depressive disorder (MDD) do
not fully respond to the first antidepressant. While switching antidepressants is a common …

Background It remains unclear regarding the contribution of each individual symptom in
predicting the outcome in major depressive disorder (MDD). The objective of this analysis …

OBJECTIVE: The primary objective of this article is to review the literature regarding the
speed of response to antidepressant drugs and potential strategies to accelerate the …

Abstract Patients with Major Depressive Disorder (MDD) and no improvement after two
weeks of antidepressant pharmacotherapy have a high risk of treatment failure. The aim of …

Background The Prospective Epidemiological Research on Functioning Outcomes Related
to Major Depressive Disorder (PERFORM) study has been initiated to better understand the …

Objective: New evidence indicates that treatment response can be predicted with high
sensitivity after 2 weeks of treatment. Here, we assess whether early improvement with …

Background The aim of the study was to determine the most common pharmacological
strategies used in the management of major depressive disorder (MDD) after an inadequate …

Rationale Traditionally, the therapeutic effect of antidepressants is thought to take several
weeks. However, several studies found evidence of early drug response occurring within the …

Importance Less than one-third of patients with major depressive disorder (MDD) achieve
remission with their first antidepressant. Objective To determine the relative effectiveness …