Despite many advances in pharmacotherapy over the past half centurye, only a fraction of
patients with Major Depressive Disorder (MDD) can achieve remission after the first or …

A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance …

The probability of achieving and sustaining symptomatic remission in major depressive
disorder (MDD) with first-line pharmacotherapy is approximately 30%. Ample documentation …

Background No study has investigated the impact of the duration of untreated depression
(DUD) on the severity of depression at the two-year follow-up point in patients with major …

Objective:(1) To directly compare the effectiveness of switching antidepressants with
augmenting them in depressed patients who do not respond to an initial adequate trial and …

Abstract Background In the Sequenced Treatment Alternatives to Relieve Depression
(STAR* D) study, a third of patients did not achieve remission or adequate response after …

There is still considerable controversy about the onset and time course of improvement with
antidepressants in the treatment of major depressive disorder. Previous studies suggested a …

Background Identifying the predictors of relapse could help to develop more individualized
treatment strategies for major depression. The study aim was to explore predictors of …

Background The efficacy, limitations, and methods of studying antidepressant treatment
continued beyond initial weeks of acute major depression remain incompletely resolved …

Major depression is often a relapsing disorder. It is therefore important to start its treatment
with therapies that maximize the chance of not only getting the patients well but also keeping …