It is increasingly recognised that major depressive disorder can be a chronic condition with
many patients experiencing recurrent episodes. Remission from a depressive episode …

Background: In patients who are not responding to antidepressant pharmacotherapy,
information regarding the future probability of response with the same treatment is scarce …

BACKGROUND: There is substantial evidence that early improvement (EI) under
antidepressant treatment is a clinically useful predictor of later treatment outcome in patients …

Major depressive disorder (MDD) is an often chronic, recurrent illness affecting large
numbers of the general population. In recent years, the goal of treatment for MDD has …

Abstract Objective. This randomized, 6-week, open-label study compared efficacy of CAD
and antidepressant monotherapies (ADM) that had been chosen according to clinical …

BACKGROUND: Treatment-resistant depression (TRD) is relatively common and accounts
for a large proportion of the overall burden caused by depression. We conducted a …

Objective: The authors sought to determine study design factors that may influence clinical
trial outcome in augmentation/combination trials for antidepressant partial responders …

Treatment for major depressive disorder does not achieve remission in about 50% of
patients following 2 treatment trials. Researchers conducted the Sequenced Treatment …

BACKGROUND: The full response to antidepressant pharmacotherapy is evident only after
several weeks, but considerable improvements may already be visible within the first two …

Objective: To examine the available scientific evidence for answers to clinically relevant
questions on the effectiveness and tolerability of antidepressant drugs (ADs) for the long …