Background: Although efficacy studies suggest equal potency among antidepressant
treatments, their effectiveness in clinical practice appears more variable, particularly in that …

Objective To determine the relative variability and magnitude of symptomatic improvement in
antidepressant-treated individuals compared to placebo-treated individuals, and to …

Objective: This observational study examined the effectiveness of somatic antidepressant
treatments as administered in the community. Method: The study group consisted of 285 …

BackgroundIndividuals with treatment-resistant depression (TRD) experience a high burden
of illness. Current guidelines recommend a stepped care approach for treating depression …

Objective The role of baseline severity as effect modifier in various psychiatric disorders is a
topic of controversy and of clinical import. This study aims to examine whether baseline …

Background: Several meta-or mega-analyses suggest antidepressant medications should
be given only to severely depressed patients. In our experience, mild depression benefits …

Objective: Current clinical knowledge holds that antidepressants have a delayed onset of
efficacy. However, the delayed onset hypothesis has been questioned recently by survival …

Objective Patients with major depressive disorder (MDD) with inadequate response to
antidepressant treatment (ADT) may suffer a prolonged loss of functioning. This review …

Abstract The Sequenced Treatment Alternatives to Relieve Depression trial enrolled
outpatients with nonpsychotic major depressive disorder treated prospectively in a series of …

Objective Few studies have compared simultaneously different antidepressants in long‐term
treatment of major depressive disorder (MDD). Long‐term prevention of recurrences should …