Background Antidepressant drugs can promote remission from acute depressive episodes.
Our aim was to establish how long such treatments should be continued to prevent relapse …

Objective: This article presents the case that a more rapid, individualized approach to
treating major depressive disorder (MDD) may increase the likelihood of achieving full …

Objective: Nonresponders to antidepressant monotherapy during acute treatment of major
depression are often switched to a new antidepressant. The objective of this meta-analysis …

Antidepressant medications generally are considered to have a delayed onset of action;
however, recent evidence is beginning to challenge this conventional wisdom. Meta …

OBJECTIVE: The aim of this study was to assess the percentages of full remission in studies
of patients with major depressive disorder in which pharmacotherapy, psychotherapy, and …

Rationale A history of antidepressant treatment may predispose subjects toward placebo
nonresponse in randomized controlled trials (RCTs) in major depressive disorder (MDD) …

Objective: To compare early sustained response rates between antidepressant-and placebo-
treated adults with major depressive disorder. Data Sources: Medline/Pubmed were …

Objective Various classes of antidepressant medications generally induce remission of
major depressive disorder in only about one-third of patients. In a previous study using …

Background Understanding patterns of relapse in patients who respond to antidepressant
treatment can inform strategies for prevention of relapse. We aimed to identify distinct …

Introduction: While the short-term response rates to antidepressant medication and placebo
are well established, very little is known about the short-term course of untreated …